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The threshold for differential expression was a log 2 fold change of + 1 for upregulated genes and 1 for downregulated genes

In these hypercatabolic states, skeletal muscle protein synthesis decreases and protein degradation increases in an attempt to supply the body with carbon skeletons for energy derivation, or amino acids to repair body damage

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After seven weeks, their cardiac function was assessed, showing those receiving NAC plus glycine had improved several parameters of their cardiovascular function, including: Improved diastolic function Increased peak early filling velocity Reduced relaxation time Reduced left atrial volume Reduced left ventricle end diastolic pressure NAC alone did not impart these cardiovascular benefits, although both groups had decreased levels of inflammatory mediators